產品屬性：
產品名稱 | Niclosamide (ethanolamine salt) |
規格 | 50mg、100mg、250mg、500mg |
貨號 | EY-01Y10142 |
Cas No.: 1420-04-8
別名: N/A
化學名: N/A
分子式: C13H8Cl2N2O4?C2H7NO
分子量: 388.2
溶解度: DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 0.25 mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. It inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling. It completely inhibits phosphorylation of ribosomal S6 kinases (S6K) when used at a concentration of 3 μM. Niclosamide (1 μM) induces mitochondrial uncoupling, decreasing cellular ATP concentrations and increasing the ratio of ADP to ATP in HepG2 cells, and activates AMP-activated protein kinase (AMPK) in NIH3T3 cells. It also increases lipid oxidation by 5-fold in HepG2 cells. It prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice when administered at a dose of at 125 mg/kg per day. Niclosamide also inhibits proliferation and colony formation of DU145 prostate cancer cells, which have constitutively active STAT3 (IC50s = 0.7 and 0.1 μM, respectively).
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