產品屬性：
產品名稱 | N-Acetyl-4-benzoquinone imine |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y10981 |
Cas No.: 50700-49-7
別名: N/A
化學名: N/A
分子式: C8H7NO2
分子量: 149.2
溶解度: Chloroform: 1 mg/ml*,Chloroform/Ethyl Acetate (1:1): 1 mg/ml,Ether: 1 mg/ml,Ethyl Acetate: 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
特別提醒公司產品僅供科研使用
