產品屬性：
產品名稱 | PK68 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y12497 |
Cas No.: 2173556-69-7
別名: N/A
化學名: N/A
分子式: C22H24N4O3S
分子量: 424.52
溶解度: DMSO: 30 mg/mL (70.67 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1].IC50: ~ 90 nM (RIPK1)[1][1]. Hou J, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.
特別提醒公司產品僅供科研使用
