產品屬性：
產品名稱 | NR-160 |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y12526 |
Cas No.: 2484895-50-1
別名: N/A
化學名: N/A
分子式: C25H21F3N6O3
分子量: 510.5
溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.03 μM).1 It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.1.Re?ing, N., S?nnichsen, M., Osko, J.D., et al.Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groupsJ. Med. Chem.63(18)10339-10351(2020)
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