產品屬性：
產品名稱 | PKA Inhibitor (5-24) (trifluoroacetate salt) |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y12701 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C94H148N32O31?XCF3COOH
分子量: 2222.4
溶解度: DMSO: 1 mg/ml,PBS (pH 7.2): 2 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1 It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.1 The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).21.Cheng, H.C., Kemp, B.E., Pearson, R.B., et al.A potent synthetic peptide inhibitor of the cAMP-dependent protein kinaseThe Journal of Biological Chemisty261(3)989-992(1986)
2.Bossemeyer, D., Engh, R.A., Kinzel, V., et al.Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 ? structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)EMBO Journal12(3)849-859(1993)
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