產品屬性：
產品名稱 | PLX5622 |
規格 | 10 mM * 1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y12872 |
Cas No.: 1303420-67-8
別名: N/A
化學名: N/A
分子式: C21H19F2N5O
分子量: 395.41
溶解度: DMSO: 83.33 mg/mL (210.74 mM); H2O: < 0.1 mg/mL (insoluble)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1].CSF1R[1].[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.
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