產品屬性：
產品名稱 | NSAH |
規格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y13046 |
Cas No.: 1099592-35-4
別名: N/A
化學名: N/A
分子式: C18H14N2O3
分子量: 306.32
溶解度: DMSO : 62.5 mg/mL (204.03 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells[1].NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines[1].NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP[1].[1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246.
特別提醒公司產品僅供科研使用
