產品屬性：
產品名稱 | 5'-Thymidylic Acid (sodium salt) |
規格 | 100mg、250mg、1g |
貨號 | EY-01Y13089 |
Cas No.: 33430-62-5
別名: N/A
化學名: N/A
分子式: C10H13N2O8P?2Na
分子量: 366.2
溶解度: PBS (pH 7.2): slightly soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
5'-Thymidylic acid (dTMP) is a deoxyribonucleotide.1 It is formed via methylation of dUMP by thymidylate synthase. It is further phosphorylated by thymidine kinase (TK) to form dTDP during nucleic acid synthesis.2 Oral administration of dTMP in combination with dCMP increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.31.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002)
2.Lee, L.S., and Cheng, Y.Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemiaJ. Biol. Chem.252(16)5686-5691(1977)
3.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)
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