產品屬性：
產品名稱 | NMS-P515 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y13130 |
Cas No.: 1262395-13-0
別名: N/A
化學名: N/A
分子式: C21H29N3O2
分子量: 355.47
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity[1].
PARP-1|16 nM (Kd)|PARP-1|27 nM (IC50, in Hela cells)
NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer[1].Animal Model:Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts[1].[1]. Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10(4):534-538.
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