產品屬性：

Cas No.: N/A

別名: N/A

化學名: N/A

分子式: C21H31ClN6O3.XCF3COOH

分子量: 451

溶解度: DMF: 33 mg/ml,DMSO: 33 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 5 mg/ml

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM).1,2,3 It has been used as an anticoagulant (100 μM) and to study thrombin-mediated fibrin deposition, angiogenesis, and proinflammatory processes.4,51.Kovach, I.M., Kelley, P., Eddy, C., et al.Proton bridging in the interactions of thrombin with small inhibitorsBiochemistry48(30)7296-7304(2009)

2.Bode, W., Turk, D., and Karshikov, A.The refined 1.9-? x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsProtein Science1(4)426-471(1992)

3.Hanson, S.R., and Harker, L.A.Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketoneProceedings of the National Academy of Sciences of the United States of America85(9)3184-3488(1988)

4.Lyon, M.E., Fine, J.S., Henderson, P.J., et al.D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): Alternative anticoagulant to heparin salts for blood gas and electrolyte specimensClinical Chemistry41(7)1038-1041(1995)

5.Liu, J.F., Hou, S.M., Tsai, C.H., et al.Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysArthritis Research & Therapy14(2)R91(2012)
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