產品屬性：

Cas No.: 2379569-17-0

別名: N/A

化學名: N/A

分子式: C28H54N8O7·XCF3COOH

分子量: 614.8

溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1 It binds to NCTC 2544 cells expressing human PAR2 (Ki = 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50 = 0.075 μM).2 PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1 It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3 PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .41.Bohm, S.K., Kong, W., Bromme, D., et al.Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2Biochem. J.314(Pt 3)1009-1016(1996)

2.Kanke, T., Ishiwata, H., Kabeya, M., et al.Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2Br. J. Pharmacol.145(2)255-263(2005)

3.Miike, S., McWilliam, A.S., and Kita, H.Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2J. Immunol.167(11)6615-6622(2001)

4.Nishikawa, H., Kawai, K., Tanaka, M., et al.Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: Involvement of PAR-2 and non-PAR-2 mechanismsJ. Pharmacol. Exp. Ther.312(2)324-331(2005)
特別提醒公司產品僅供科研使用