產品屬性：
產品名稱 | PF 9601N |
規格 | 5 mg、10 mg、25 mg、50 mg |
貨號 | EY-01Y13554 |
Cas No.: 133845-63-3
別名: N/A
化學名: N/A
分子式: C19H18N2O
分子量: 290.4
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 20 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PF 9601N is an inhibitor of monoamine oxidase B (MAO-B).1 It selectively inhibits MAO-B in mouse brain homogenates ex vivo (ID50 = 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 μmol/kg. PF 9601N (0.027 μmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA when administered at doses of 40 and 60 mg/kg.21.Perez, V., and Unzeta, M.PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 miceNeurochem. Int.42(3)221-229(2003)
2.Prat, G., Pérez, V., Rubi, A., et al.The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned ratsJ. Neural Transm. (Vienna)107(4)409-417(2000)
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