產品屬性：
產品名稱 | Norfluoxetine-d5 (hydrochloride) |
規格 | 1 mg、5 mg |
貨號 | EY-01Y14744 |
Cas No.: 1185132-92-6
別名: N/A
化學名: N/A
分子式: C16H11D5F3NO·HCl
分子量: 336.8
溶解度: Chloroform: slightly soluble,DMSO: slightly soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1 It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2 Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM).1 It has been found in the tissues of fish exposed to wastewater effluent.31.Wong, D.T., Bymaster, F.P., Reid, L.R., et al.Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brainNeuropsychopharmacology8(4)337-344(1993)
2.Hiemke, C., and H?rtter, S.Pharmacokinetics of selective serotonin reuptake inhibitorsPharmacol. Ther.85(1)11-28(2000)
3.Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al.Determination of select antidepressants in fish from an effluent-dominated streamEnviron. Toxicol. Chem.24(2)464-469(2005)
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