產品屬性：
產品名稱 | Nifuroxazide-d4 |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y14719 |
Cas No.: 1188487-83-3
別名: N/A
化學名: N/A
分子式: C12H5D4N3O5
分子量: 279.2
溶解度: DMF: soluble,DMSO: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic.1 It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli.1 It inhibits quorum sensing and virulence factor production in P. aeruginosa.2 Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 μM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 μM for both.3 It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells.4 Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.51.Vanhoof, R., Coignau, H., Stas, G., et al.Evaluation of the in vitro activity of nifuroxazide on enteropathogenic microorganisms: Determination of bacteriostatic and bactericidal concentrations and disk susceptibilityActa Clin. Belg.36(3)126-129(1981)
2.Yang, L., Rybtke, M.T., Jakobsen, T.H., et al.Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitorsAntimicrob. Agents Chemother.53(6)2432-2443(2009)
3.Nelson, E.A., Walker, S.R., Kepich, A., et al.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3Blood112(13)5095-5102(2008)
4.Yang, F., Hu, M., Lei, Q., et al.Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer modelCell Death Dis.6(3)e1701(2015)
5.El-Far, Y.M., Elsherbiny, N.M., El-Shafey, M., et al.The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in ratsEnviron. Toxicol. Pharmacol.79103433(2020)
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