產品屬性：
產品名稱 | Norgestimate-d6 |
規格 | 500 μg、1 mg |
貨號 | EY-01Y14790 |
Cas No.: 1263194-12-2
別名: N/A
化學名: N/A
分子式: C23H25D6NO3
分子量: 375.5
溶解度: Methanol: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Norgestimate-d6 is intended for use as an internal standard for the quantification of norgestimate by GC- or LC-MS. Norgestimate is a progestin and a prodrug form of norelgestromin and levonorgestrel .1,2 It binds to progestin receptors (mean IC50 = 3.48 nM for rabbit uterine receptors) and is selective for progestin over androgen receptors (mean IC50 = 764 nM for rat prostatic receptors) in radioligand binding assays.3 Norgestimate maintains pregnancy in ovariectomized female rats in a dose-dependent manner.1 It inhibits ovulation in 100% of female rats when administered at a dose of 0.5 mg/kg. Norgestimate (2 mg/kg) completely inhibits estrone-induced vaginal cornification in ovariectomized female rats, indicating antiestrogenic activity. Formulations containing norgestimate in combination with ethinyl estradiol have been used as oral contraceptives and in the treatment of acne vulgaris.1.Hahn, D.W., Allen, G.O., and McGuire, J.L.The pharmacological profile of norgestimate, a new orally active progestinContraception16(5)541-553(1977)
2.Stanczyk, F.Z.All progestins are not created equalSteroids68(10-13)879-890(2003)
3.Phillips, A., Demarest, K., Hahn, D.W., et al.Progestational and androgenic receptor binding affinities and in vivo activities of norgestimate and other progestinsContraception41(4)399-410(1990)
特別提醒公司產品僅供科研使用
