產品屬性：
產品名稱 | N-Phenylthiourea |
規格 | 25 g、50 g、100 g、250 g |
貨號 | EY-01Y14870 |
Cas No.: 103-85-5
別名: N/A
化學名: N/A
分子式: C7H8N2S
分子量: 152.2
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
N-Phenylthiourea is a tyrosinase inhibitor (Ki = 0.21 μM in an enzyme assay using L-DOPA as a substrate) and building block.1,2 It increases the susceptibility of SK-MEL-188 melanoma cells in melanogenesis-inducing conditions to γ-radiation-induced cytotoxicity when used at a concentration of 0.01 μM.3 N-Phenylthiourea has been used as a precursor in the synthesis of compounds with antibacterial and antifungal activities.2 It has also been used as a genetic marker for taste because only some people detect it as a bitter taste.41.Ryanzanova, A.D., Alekseev, A.A., and Slepneva, I.A.The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidaseJ. Enzyme Inhib. Med. Chem.27(1)78-83(2012)
2.Soni, B., Bhandari, A.A., Ranawat, M.S., et al.Synthesis and antimicrobial activity of 2-substituted benzothiazole containing azomethine linkagePharmacophore2(1)24-33(2011)
3.Bro?yna, A.A., VanMiddlesworth, L., and Slominski, A.T.Inhibition of melanogenesis as a radiation sensitizer for melanoma therapyInt. J. Cancer123(6)1448-1456(2008)
4.Drewnowski, A., and Rock, C.L.The influence of genetic taste markers on food acceptanceAm. J. Clin. Nutr.62(3)506-511(1995)
特別提醒公司產品僅供科研使用
