產品屬性:
產品名稱 | Oleoyl Ethanolamide-d4 |
規格 | 100 μg、500 μg、1 mg、5 mg |
貨號 | EY-01Y15187 |
Cas No.: 946524-36-3
別名: N/A
化學名: N/A
分子式: C20H35D4NO2

分子量: 329.6
溶解度: DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 100 μg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述:
Oleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1',2, and 2' positions. It is intended for use as an internal standard for the quantification of oleoyl ethanolamide by GC- or LC-mass spectrometry. Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.1 It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2 but its biosynthesis is reduced in the intestine of rats following food deprivation.3 OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay.4 Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.3,4 These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.1.di Tomaso, E., Beltramo, M., and Piomelli, D.Brain cannabinoids in chocolateNature382677-678(1996)
2.Epps, D.E., Palmer, J.W., Schmid, H.H.O., et al.Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acelethanolamines, a class of lipids synthesized in ischemic heart tissueThe Journal of Biological Chemisty2571383-1392(1982)
3.de Fonseca, F.R., Navarro, M., Gómez, R., et al.An anorexic lipid mediator regulated by feedingNature414209-212(2001)
4.Fu, J., Gaetani, S., Oveisi, F., et al.Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-αNature42590-93(2003)
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