產品屬性：
產品名稱 | PF-06263276 |
規格 | 5mg、10mg |
貨號 | EY-01Y15168 |
Cas No.: 1421502-62-6
別名: N/A
化學名: N/A
分子式: C31H31FN8O2
分子量: 566.63
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].
JAK1|2.2 nM (IC50)|JAK2|23.1 nM (IC50)|JAK3|59.9 nM (IC50)|Tyk2|29.7 nM (IC50)
[1]. Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786.
特別提醒公司產品僅供科研使用
