產品屬性：
產品名稱 | PF-04995274 |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y15224 |
Cas No.: 1331782-27-4
別名: N/A
化學名: N/A
分子式: C23H32N2O6
分子量: 432.5
溶解度: Chloroform: 30 mg/ml,DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.|1. Brodney, M.A., Johnson, D.E., Sawant-Basak, A., et al. Identification of multiple 5?HT4 partial agonist clinical candidates for the treatment of alzheimer's disease. J. Med. Chem. 55(21), 9240-9254 (2012).
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