產品屬性：
產品名稱 | Pamoic Acid |
規格 | 50g、100g、250g |
貨號 | EY-01Y15287 |
Cas No.: 130-85-8
別名: N/A
化學名: N/A
分子式: C23H16O6
分子量: 388.4
溶解度: DMSO: 0.2 mg/ml,Methanol: slightly soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay). It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a. In vivo, pamoic acid has antinociceptive effects with an ED50 value of 40.5 mg/kg in a mouse abdominal constriction model of visceral pain perception. Pamoate salts, of which pamoic acid is the main constituent, have been used in drug formulations to extend the duration of action.
特別提醒公司產品僅供科研使用
