產品屬性：
產品名稱 | Naphthofluorescein |
規格 | 5mg、10mg、50mg |
貨號 | EY-01Y16849 |
Cas No.: 61419-02-1
別名: N/A
化學名: N/A
分子式: C28H16O5
分子量: 432.4
溶解度: DMF: 10 mg/ml,DMF:PBS (pH 7) (1:10): 0.09 mg/ml,DMSO: 3 mg/ml,Ethanol: 2 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
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