產品屬性：
產品名稱 | Nimodipine-d7 |
規格 | 500 μg、1 mg |
貨號 | EY-01Y16854 |
Cas No.: 1246815-36-0
別名: N/A
化學名: N/A
分子式: C21H19D7N2O7
分子量: 425.5
溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Nimodipine-d7 is intended for use as an internal standard for the quantification of nimodipine by GC- or LC-MS. Nimodipine is an inhibitor of L-type voltage-gated calcium (Cav) channels.1 It is selective for Cav1.2 over Cav1.3 channels (IC50s = 0.139 and 2.7 μM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 μM.1,2 Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.3 It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).41.Furukawa, T., Yamakawa, T., Midera, T., et al.Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytesJ. Pharmacol. Exp. Ther.291(2)464-473(1999)
2.Xu, W., and Lipscombe, D.Neuronal Cav1.3ɑ1 L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridinesJ. Neurosci.21(16)5944-5951(2001)
3.Kazda, S., and Towart, R.Nimodipine: A new calcium antagonistic drug with a preferential cerebrovascular actionActa Neurochir. (Wien)63(1-4)259-265(1982)
4.Babu, C.S., and Ramanathan, M.Post-ischemic administration of nimodipine following focal cerebral ischemic-reperfusion injury in rats alleviated excitotoxicity, neurobehavioural alterations and partially the bioenergeticsInt. J. Dev. Neurosci.29(1)93-105(2011)
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