產品屬性：
產品名稱 | PF-1163A |
規格 | 500μg、2.5mg |
貨號 | EY-01Y16925 |
Cas No.: 258871-59-9
別名: N/A
化學名: N/A
分子式: C27H43NO6
分子量: 477.6
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PF-1163A is a depsipeptide antifungal isolated from Penicillium that inhibits ergosterol synthesis (IC50 = 12 ng/ml). In S. cerevisiae transfected with ERG biosynthesis genes, PF-1163 inhibits ERG25p, a C-4 methyl oxidase in the ERG biosynthetic pathway, with a MIC value of 12.5 μg/ml, while a strain overexpressing ERG25p is resistant. It inhibits growth of C. albicans (MIC = 8 μg/ml) but not of other Candida strains, A. fumigatus, or HepG2 cells. It also acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans (MICs = 1 and 0.0078 μg/ml alone and in combination, respectively). PF-1163A is a more polar form of PF-1163B .
特別提醒公司產品僅供科研使用
