產品屬性：
產品名稱 | N-dodecanoyl-L-Homoserine lactone |
規格 | 5mg、10mg、25mg、50mg |
貨號 | EY-01Y17054 |
Cas No.: 137173-46-7
別名: C12-HSL
化學名: N-[(3S)-tetrahydro-2-oxo-3-furanyl]-dodecanamide
分子式: C16H29NO3
分子量: 283.4
溶解度: 30mg/ml in DMSO, or in DMF
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. [1][2][3] In addition to regulating bacterial functions, C12-HSL activates NF-κB in RAW 264.7 macrophages, increasing the expression of TNF-α, interleukin-1β (IL-1β), and IL-8, while other lactones do not.[4] In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-Homoserine lactone which is produced at different times in biofilm development[6] and has different cellular effects.[5]
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