產品屬性：
產品名稱 | PAF C-16-d4 |
規格 | 100 μg、500 μg、1 mg |
貨號 | EY-01Y17122 |
Cas No.: 211106-54-6
別名: N/A
化學名: N/A
分子式: C26H50D4NO7P
分子量: 527.7
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS pH 7.2: 25 mg/ml,Water: 30 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PAF C-16-d4 contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.1 It is a potent mediator of neutrophil migration,2 the production of reactive oxygen species,3 and IL-64 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-185. Pathological processes involving PAF include necrotizing enterocolitis,6 inflammation, asthma, and allergy.71.Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorThe Journal of Biological Chemisty26517381-17384(1990)
2.Carolan, E.J., and Casale, T.B.Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular speciesJournal of Immunology1452561-2565(1990)
3.Rouis, M., Nigon, F., and Chapman, M.J.Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophagesBiochemical and Biophysical Research Communications1561293-1301(1988)
4.Thivierge, M., and Rola-Pleszczynski, M.Platelet-activating factor enhances interleukin-6 production by alveolar macrophagesJournal of Allergy and Clinical Immunology90796-802(1992)
5.Stewart, A.G., and Grigoriadis, G.Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophagesJournal of Lipid Mediators4299-308(1991)
6.Wang, H., Tan, X.D., Qu, X.W., et al.Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximidePediatric Research42597-603(1997)
7.Sturk, A., Wouter Ten Cate, J., Hosford, D., et al.The synthesis, catabolism, and pathophysiological role of platelet-activating factorAdvances in Lipid Research23219-276(1989)
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