產品屬性：
產品名稱 | PSI-7977-13C-d3 |
規格 | 1 mg |
貨號 | EY-01Y17181 |
Cas No.: 2070009-25-3
別名: N/A
化學名: N/A
分子式: C21[13C]H26D3FN3O9P
分子量: 533.5
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).1,2,3 PSI-7977 is effective in vitro and in vivo.2,4,5
1.Murakami, E., Tolstykh, T., Bao, H., et al.Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977J. Biol. Chem.285(45)34337-34347(2010)
2.Sofia, M.J., Bao, D., Chang, W., et al.Discovery of a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virusJ. Med. Chem.53(19)7202-7218(2010)
3.Lam, A.M., Espiritu, C., Bansal, S., et al.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virusAntimicrob. Agents Chemother.56(6)3359-3368(2012)
4.Gane, E.J., Stedman, C.A., Hyland, R.H., et al.Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis CN. Engl. J. Med.368(1)34-44(2013)
5.Lawitz, E., Mangia, A., Wyles, D., et al.Sofosbuvir for previously untreated chronic hepatitis C infectionN. Engl. J. Med.368(20)1878-1887(2013)
特別提醒公司產品僅供科研使用
